Combined modality therapy of rectal cancers
نویسندگان
چکیده
منابع مشابه
Combined-modality therapy of rectal cancer with irinotecan-based regimens.
There are two conventional treatments for clinically resectable rectal cancer. The first is surgery followed by postoperative combined-modality therapy if the tumor is T3 and/or N1/2. The second, if the tumor is ultrasound T3 or clinical T4, is preoperative combined-modality therapy followed by surgery and postoperative chemotherapy. There are a number of new chemotherapeutic agents that have b...
متن کاملCombined-Modality Therapy of Rectal Cancer With Irinotecan- Based Regimens
There are two conventional treatments for clinically resectable rectal cancer. The first is surgery followed by postoperative combinedmodality therapy if the tumor is T3 and/or N1/2. The second, if the tumor is ultrasound T3 or clinical T4, is preoperative combined-modality therapy followed by surgery and postoperative chemotherapy. There are a number of new chemotherapeutic agents that have be...
متن کاملAdjuvant postoperative combined-modality therapy for rectal cancer.
A number of advances have been made in the use of adjuvant chemotherapy for resectable rectal cancer. Whereas pelvic radiation therapy has been shown to increase local control in patients with clinically resectable disease, systemic chemotherapy is needed in addition to further improve local control and overall survival. In this review, the experience treating patients with clinically resectabl...
متن کاملCombined-modality therapy for rectal cancer using irinotecan.
Preoperative or postoperative pelvic radiation plus concurrent fluorouracil-based chemotherapy is standard adjuvant treatment for patients with T3 and/or N1/2 rectal cancer. Newer chemotherapeutic regimens have been developed for the treatment of patients with metastatic disease. Irinotecan (CPT-11, Camptosar)-based regimens have improved survival in patients with metastatic disease and are bei...
متن کاملIrinotecan in preoperative combined-modality therapy for locally advanced rectal cancer.
Irinotecan (CPT-11, Camptosar) is a semisynthetic water-soluble derivative of the plant alkaloid camptothecin. This review will focus on the potential use of irinotecan in combination with fluorouracil (5-FU) in the preoperative combined-modality treatment of advanced rectal cancer. The laboratory studies that define the mechanism of fluoropyrimidine- and camptothecin-mediated radiosensitizatio...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1999
ISSN: 0923-7534
DOI: 10.1093/annonc/10.suppl_6.s99